鬼筆環肽是一種雙環七肽毒素，特異性結合在F-肌動蛋白亞基之間的界面上，將相鄰的亞基鎖定在一起。鬼筆環肽與肌動蛋白絲的結合比與肌動蛋白單體的結合要緊密得多，從而導致肌動蛋白亞基從絲端解離的速率常數降低，因此通過防止絲解聚而基本穩定了肌動蛋白絲，終，發現鬼筆環肽抑制F-肌動蛋白的ATP水解活性。

鬼筆環肽的性質是研究F-肌動蛋白在細胞中分布的有用工具，方法是用熒光類似物標記鬼筆環肽并將其用于染色肌動蛋白絲以進行光學顯微鏡檢查。鬼筆環肽的熒光衍生物已被證明在尋找活細胞或固定細胞中的肌動蛋白絲以及體外觀察單個肌動蛋白絲方面非常有用。熒光鬼筆環肽衍生物已被用作高分辨率研究肌動蛋白網絡的重要工具。AAT Bioquest可以提供多色成像應用的鬼筆環肽。

參考文獻

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公司簡介
西安百螢生物科技有限公司是一家專注從事生物、化學試劑及其試劑盒的高新技術企業；主要以熒光探針，分子探針，核酸/蛋白質標記、細胞檢測等技術和產品為研發核心，產品應用于基因合成、細胞檢測、活體示蹤，抗體標記、新藥篩選等領域。